This study compares the efficacy and tolerability/comfort of brimonidine/timolol and dorzolamide/timolol in patients with open-angle glaucoma or ocular hypertension. In an investigator masked randomisation process, each subject is allocated to received either brimonidine/timolol or dorzolamide/timolol as fixed-combination monotherapy or as an adjunctive to a prostaglandin analogue for a period of 12 weeks. After screening, patient returns at baseline, Month 1 and Month 3 for ophthalmic evaluations.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
140
1 drop BID in each eye
1 drop BID in each eye
1 drop BID in each eye
Unnamed facility
Barrie, Ontario, Canada
Change from baseline in mean IOP
Time frame: 12 weeks
Patient tolerability/comfort measured by Likert scale
Time frame: Month 1
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