Efficacy and Safety of Four Escalating Dose Regimens of TPI ASM8 in Patients With Allergic Asthma

Inclusion Criteria: * Men and women 18 to 65 years of age * Generally good health; steroid naïve (or who have not taken inhaled/oral corticosteroid within last month) mild to moderate, stable, allergic asthma as defined by ATS criteria * History of episodic wheeze and shortness of breath * Forced expiratory volume in one second (FEV1) at baseline ≥ 70% of the predicted value * Able to comprehend and follow all required study procedures; willing and able to sign an informed consent form. Exclusion Criteria: * Significant acute or chronic medical or psychiatric illness * Known coagulopathy, worsening of asthma or respiratory infection in the preceding 6 weeks * Use of inhaled or oral corticosteroids within the last 30 days, or need for antihistamines within 72 hours of each allergen or methacholine challenge, immunosuppressives, nonsteroidal anti-inflammatory drugs, or anticoagulants (intermittent doses of short-acting β2-agonist are allowed).