The aim of this study is to investigate the effects of taking repeated doses of AZD6280 on the blood levels of midazolam and caffeine in healthy volunteers
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
24
Research Site
London, United Kingdom
To determine the effects of repeated doses of AZD6280 on the pharmacokinetic profile of a CYP3A4 substrate (midazolam and its 1' hydroxy metabolite) and a CYP1A2 substrate (caffeine and its paraxanthine [3-desmethyl] metabolite).
Time frame: Blood samples will be taken throughout the 19-day inpatient period of the study.
To evaluate the safety and tolerability of repeated doses of AZD6280 in combination with midazolam and caffeine.
Time frame: Observations taken post dosing.
Evaluation of the pharmacodynamic effects of AZD6280
Time frame: Test batteries will be performed before and following study drug administration.
To evaluate the pharmacokinetics of AZD6280
Time frame: Blood samples will be taken throughout the 19-day inpatient period of the study.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.