Dexamethasone for Postoperative Nausea and Vomiting

University of Jordan180 enrolled

Overview

The investigators want to test the efficacy of these anesthetic antiemetic measures collectively with or without ondansetron or dexamethasone, in the prevention of postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy.

More than half of the patients undergoing laparoscopic cholecystectomy will have postoperative nausea and vomiting (PONV). PONV is related to surgical, anesthetic and patient factors. We want to test the efficacy of these anesthetic antiemetic measures collectively with or without ondansetron or dexamethasone, in the prevention of PONV in patients undergoing laparoscopic cholecystectomy. Three groups to be studied : (Group O) will receive 4 mg ondansetron, (Group D) will receive 8 mg dexamethasone and (Group P) will receive normal saline .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

180

Conditions

Postoperative Nausea and Vomiting

Interventions

DexamethasoneDRUG

8 mg, Intravenous

OndansetronDRUG

4 mg, intravenously

normal salineDRUG

2 ml, intravenously

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * (ASA) grade I and II, aged (18-70 years) who are scheduled for elective laparoscopic cholecystectomy under general anesthesia at the department of Anesthesia and Intensive Care, University of Jordan, Amman, Jordan between November 2007 and March 2008 Exclusion Criteria: * All patients who received antiemetics or cortisone within 48 hr before surgery or those who required opioids before and after surgeries * Pregnant, breast feeding ladies * Any patient with BMI (Body Mass Index) \> 34 kg/m² * Patient with gastrointestinal, hepatic, renal, mental or psychiatric illnesses or those with history of motion sickness were also excluded from the study protocol

Locations (1)

Jordan University Hospital

Amman, Jordan

Outcomes

Primary Outcomes

incidence of nausea and vomiting in each of the three studied groups.

Time frame: 5 months

Secondary Outcomes

Assess the postoperative Visual Analog Score for pain assessment in each of the three studied groups

Time frame: 5 months

Data from ClinicalTrials.gov

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