Effect of Dietary Fiber on Glucose & Lipids in Non Insulin Dependent Diabetes Mellitus (NIDDM)

University of Texas Southwestern Medical Center13 enrolled

Overview

Effect of Dietary Fiber on glucose, lipid, and mineral metabolism in patients with non insulin dependent diabetes mellitus.

Two diets will be compared,a low fiber diet and a high fiber diet. These two diets will differ only in the content of total dietray fiber derived from natural food products. The diets will be identical in terms of total energy, percentage of total energy as proteins, fat and carbohydrates.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Non-Insulin-Dependent Diabetes Mellitus

Interventions

High Fiber and Moderate Fiber DietsOTHER

Dietary

Eligibility

Sex: ALLMin age: 35 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * NIDDM * age 35 to 80 years * stable oral hypoglycemic treatment for at least one month * fasting triglycerides \< 500 mg/dl Exclusion Criteria: * insulin dependent NIDDM * insulin dependent diabetes * hepatic disease * significant hepatic dysfunction * signifiacnt renal dysfunction * presence of significant hematological, neurological, cardiovascular or gastrointestinal disorder, unless stable for past 6 months, * serious intercurrent illness or anticipated major surgery * female pregnant or likely to become pregnant * chronic drug abuse, alcoholism or psychaitric disorder within the past 2 years * treated with beta adrenergic blockers * on lipid lowering drugs

Outcomes

Primary Outcomes

glucose and lipid metabolism

Time frame: Baseline and during the last 5 days of each 6 week dietary phase

Secondary Outcomes

calcium isotope absorption in the gastrointestinal tract, stool mineral content, 24 h urinary mineral concentration, and serum chemistry including mineral concentration.

Time frame: Baseline and during the last 5 days of each 6 week dietary phase

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.