Dose Escalation Study of ARQ 621 in Adult Patients With Metastatic Solid Tumors and Hematologic Malignancies

Inclusion Criteria: * Signed written informed consent must be obtained and documented according to International Conference on Harmonisation (ICH)- Good Clinical Practice (GCP), the local regulatory requirements, and permission to use private health information in accordance with the Health Insurance Portability and Accountability Act (HIPPA) prior to study-specific screening procedures * A histologically or cytologically confirmed metastatic solid tumor or refractory/relapsed hematologic malignancy * Have a life expectancy of at least 12 weeks * ≥18 years of age * Measurable disease as defined by: * Solid Tumors: Response Evaluation Criteria in Solid Tumors * Multiple Myeloma (MM): International Uniform Response Criteria, at least one of the following: * Monoclonal protein in the plasma of ≥0.5 g/dL * Monoclonal protein in the urine of ≥0.2 g/24 hr urine collection * Serum immunoglobulin free light chain (FLC) ≥100 mg/L (10 mg/dL) and abnormal serum immunoglobulin kappa to lambda FLC ratio * Malignant Lymphoma (ML): International Working Group Response Criteria * At least one site of disease ≥2 cm in longest diameter (a lesion ≥1 cm can be considered if PET positive) * Chronic Lymphocytic Leukemia (CLL): NCI Working Group Guidelines * Lymphocytosis (5 x 10\^9 /L) with B-cell marker (CD19, CD20,CD23) + CD5 * High-risk characteristics (hemoglobin \<10g/dL OR platelets \<100 x 10\^9 /L) * Acute Myelogenous Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL): only patients with bone marrow or peripheral blast count of ≥20% * Acute Promyelocytic Leukemia (APML): patients must be refractory to all-trans retinoic acid (ATRA) and arsenic trioxide * Chronic Myelogenous Leukemia (CML): patients in blast crisis (bone marrow or peripheral blast count ≥20%) may be included if refractory to prior therapy and to any therapy the investigators deems of higher priority (for example, BCR-ABL inhibitors such as imatinib mesylate \[Gleevec\], nilotinib \[Tasigna\], or dasatinib \[Sprycel\]) * ECOG performance status ≤2 * Male or female patients of child-producing potential must agree to use contraception or avoidance of pregnancy measures during the study and for 30 days after the last ARQ 621 dose * Females of childbearing potential must have a negative serum pregnancy test * Aspartate transaminase (AST) and alanine transaminase (ALT) ≤2.5 × upper limit of normal (ULN) or ≤5.0 × ULN with metastatic liver disease * Hemoglobin (Hgb) ≥10 g/dL (except in cases considered related to hematologic malignancy) * Total bilirubin ≤1.5 × ULN * Creatinine ≤1.5 x ULN (≤2.0 x ULN in cases considered related to multiple myeloma) * Absolute neutrophil count ≥1.5 x 10\^9/L (except in cases considered related to hematologic malignancy) * Platelets ≥100 x 10\^9/L (except in cases considered related to hematologic malignancy) * Patients with hematologic malignancies who have progressed following at least two prior treatment regimens Exclusion Criteria: * Anti-cancer chemotherapy, radiotherapy, immunotherapy, or investigational agents within four weeks of the first dose * In cases of hematologic malignancies, 4-week recovery from prior anticancer treatment is not required, however the patient must recover from prior treatment-related non-hematological toxicities to grade 2 or less * When required for supportive care corticosteroids or hydroxyurea may be used * Surgery within four weeks prior to the first dose * Known untreated brain metastases or leptomeningeal disease * Patients with solid tumors who were treated for brain metastases and who have shown stable disease for at least 8 weeks prior to enrollment will be allowed * Pregnant or breastfeeding * Uncontrolled concurrent illness including, but not limited to ongoing or active symptomatic infection requiring systemic therapy, clinically significant non-healing or healing wounds, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, significant pulmonary disease (shortness of breath at rest or mild exertion), uncontrolled infection or psychiatric illness/social situations that would limit compliance with study requirements * Patients having a history of Thrombotic thrombocytopenic purpura (TTP) or Hemolytic-uremic syndrome (HUS) or HUS spectrum will be excluded from the study