Inflammatory Genetic Polymorphism and Acute Lung Injury After Cardiac Surgery

Changhai Hospital107 enrolled

Overview

Acute lung injury is a common complication of cardiac surgery with cardiopulmonary bypass, and it is significantly related to prolonged postoperative recovery, hospital stays and medical cost. Currently available predictors of acute lung injury after cardiac surgery are still limited within clinical data. Several genetic polymorphism of inflammatory mediators have been reported to be associated with severity of sepsis and ARDS, but the association of these inflammatory polymorphism and acute lung injury after cardiac surgery has never been reported. This study is performed to investigate the association of genetic polymorphisms including TNF -308A/G, IL-10 -1082A/G and IL-6 -572C/G and postoperative lung injury.

Study Type

OBSERVATIONAL

Enrollment

107

Conditions

Acute Lung Injury

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Chinese Han unrelated population * adult patients * undergoing elective cardiac surgery with CPB Exclusion Criteria: * malignant tumor * autoimmune disease, immunodeficiency or immunosuppressive therapy * chronic renal disease (glomerular filtration rate \< 60ml/(min•1.73m2)) or liver dysfunction (Child Pugh classification\>A) * COPD, tuberculosis or other chronic pulmonary diseases * anemia with hemoglobin lower than 90mmHg * bleeding disorders * postoperative pericardial tamponade requiring re-operation * postoperative low cardiac output syndrome or acute pulmonary edema after left cardiac failure.

Locations (1)

Outcomes

Primary Outcomes

Acute lung injury after cardiac surgery with cardiopulmonary bypass

Time frame: 24h after surgery

Secondary Outcomes

circulating level of CRP, TNF-alpha, IL-10, IL-6; APACHE Ⅱ score; postoperative kidney injury, duration of ventilation, ICU stay and hospitalization; death in 28 days

Time frame: 24h and 1 month after surgery