Preventing Childhood Antibiotic-associated Diarrhea by Prebiotics

Soroka University Medical Center200 enrolled

Overview

Prospective randomized double-blind study on the effect of prebiotics (inulin and fructo-oligosaccharides) in the prevention of antibiotic-associated diarrhea in children.

Group will get either the product or placebo blindly throughout antibiotic treatment with additional 14 days.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

200

Conditions

Antibiotic-Associated Diarrhea

Interventions

Inulin and fructo-oligosaccharides.DIETARY_SUPPLEMENT

Supplement during antibiotic treatment+14 days.

PlaceboDIETARY_SUPPLEMENT

Placebo is base powder of product with no oligosaccharides.

Eligibility

Sex: ALLMin age: 6 MonthsMax age: 14 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy children with acute infection. Exclusion Criteria: * Hypersensitivity to antibiotics, chronic illness.

Locations (1)

Soroka Medical Center

Beersheba, Israel

Outcomes

Primary Outcomes

Prevention of diarrhea.

Time frame: During antibiotic treatment+14 days

Secondary Outcomes

Duration of diarrhea.

Time frame: During antibiotic treatment+14 days

Data from ClinicalTrials.gov

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