Canadian Study of Prediction of Risk and Evolution to Dialysis, Death and Interim Cardiovascular Events Over Time

University of British Columbia2,602 enrolled

Overview

This study will follow 2500 prevalent Chronic Kidney Disease (CKD) patients with Glomerular Filtration Rate (GFR) from 15-45 ml/min for 30 months with serial measurements every 6 months and subsequent annual chart review up to 60 months. This observational study will analyze the demographics, clinical status, medications and blood and urine samples of these patients and study the conventional biochemical, hormonal and metabolic parameters assessing which underlying biomarkers reflect the processes involved with disease progression.

Study Type

OBSERVATIONAL

Enrollment

2,602

Conditions

Chronic Kidney Disease

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients currently seen by a nephrologist, or referred for evaluation of CKD * GFR between 15-45 ml/min * Adults 19 years (depending on age of consent in province) or older * At pediatric sites study participants will be eligible to participate at age 15 or older Exclusion Criteria: * Organ transplant recipient * Life expectancy less than 12 months * Acute Vasculitis * Bioimpedance sub-study exclusion criteria: * Amputation (readings are inaccurate) * Any battery operated or electronic implanted device (such as pacemaker or implanted defibrillator - potential electrical hazard) * Pregnant women

Locations (25)

Foothills Hospital

Calgary, Alberta, Canada

University of Alberta

Edmonton, Alberta, Canada

Penticton Regional Hospital

Penticton, British Columbia, Canada

BC Children's Hospital

Vancouver, British Columbia, Canada

St. Paul's Hospital

Vancouver, British Columbia, Canada

Vancouver General Hospital

Vancouver, British Columbia, Canada

St. Boniface Hospital

Winnipeg, Manitoba, Canada

Eastern Regional Health Authority, Health Sciences Centre

St. John's, Newfoundland and Labrador, Canada

QEII Health Sciences Centre

Halifax, Nova Scotia, Canada

Cape Breton District Health Authority

Sydney, Nova Scotia, Canada

...and 15 more locations

Outcomes

Primary Outcomes

Renal Replacement Therapy

Renal Replacement Therapy is defined as dialysis start or transplantation.

Time frame: 6 monthly for 3 years, annually up to 5 years

Cardiovascular events

Cardiovascular events are defined as myocardial infarction, ischemic and hemorrhagic stroke, coronary revascularization, congestive heart failure, peripheral bypass and gangrenes, adjudicated by a nephrologist, cardiologist and neurologist.

Time frame: 6 monthly for 3 years, annually up to 5 years

Death

Deaths are reported with source documentation and adjudicated for ischemic or congestive cardiovascular death, other cardiovascular death, non-cardiovascular death and unknown cause of death.

Time frame: 6 monthly for 3 years, annually up to 5 years