We hope to learn the clinical and functional signs of sub-clinical vitamin B12 deficiency and its response to supplementation in non-anemic, non-pregnant, and non-lactating women in Rural Mexico. Vitamin B12 is important in hematopoiesis, neuro-cognitive functions and genetic integrity. However vitamin B12 is only found in animal source foods therefore a large segment of the population in developing countries and those practicing vegetarianism are at risk of deficiency of the vitamin. This information will help decide weather supplementation with vitamin B12 is necessary in such populations for public health reasons.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
TRIPLE
Enrollment
180
500 microgram daily supplement of vitamin B12 1000 mg injection vitamin B12 given at the start of the study
placebo given as a daily supplement 1000 mg injection of vitamin B12 given at the end of the study
Universidad Autonoma de Queretaro
Querétaro, Mexico
response to B12 supplementation in serum B12, Methylmalonic acid, homocystein, and holotranscobalamin concentrations
Time frame: 0 and 3 mos
DNA methylation change, and hematological response to B12 supplementation
Time frame: 0 and 3 mos
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