Improving Human Ovarian Transplantation

Early Phase 1UnknownNCT00827476

Hadassah Medical Organization100 enrolled

Overview

we will perform xenotransplantation and in vitro culture of ovarian tissue from patients undergoing ovarian cortex cryopreservation.

Ovarian tissue is removed by laparoscopy and only in patients facing premature ovarian failure due to chemotherapy.Tissue for research will consist either of a small portion (\<10%) of the cortex for preservation for young women. another source of ovarian tissue for research will be obtained following consent from family of patients who have died of the disease and have previously frozen ovarian tissue.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Fertility Preservation

Interventions

ovarian transplantationPROCEDURE

ovarian xenotransplantation or in vitro culture

Eligibility

Sex: FEMALEMin age: 5 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * tissue previously obtained Exclusion Criteria: * no tissue available or no consent

Outcomes

Primary Outcomes

improving folliculogenesis and oocuyte maturation after ovarian transplantation

Time frame: 2 years

Data from ClinicalTrials.gov

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