Pharmacodynamics and Non-Clinical Inferiority of Heparin Sodium (Cristália) Compared With the Product Liquemine (Roche) in Chronic Renal Failure

Inclusion Criteria: * Adults of both sexes, regardless of color or social class * Age over 18 years with a good clinical medical criteria * Patients who agreed to participate and signed the Informed Consent * Insufficient patients in chronic renal dialysis schedule (3 times per week) * Patients with creatinine clearance \<30ml/min * Patients with indication for anticoagulation during hemodialysis Exclusion Criteria: * Patients with sensitivity to heparin sodium; * Patients with hypersensitivity to benzyl alcohol * Patients with a history of bleeding or illness that can change the blood coagulation aggravate or terminate the clinical picture, such as tables of gastric ulcer * Patients with a history of peptic ulcer * Patients with body mass index greater than 30 * Cancer patients because of the possibility of compromising the function of the variable coagulation * Patients in period of pregnancy or after delivery * Patients with genetic abnormality of the clotting system * Polytraumatized patients * Patients using glucocorticoids for at least 1 month * Patients using other anticoagulants * Patients with high rate of bleeding * Patients undergoing any surgery performed less than 15 days due to the risk of training of hematoma at the site of surgery * Hypertension above 140/90 mmHg * Patients using medications that could affect hemostasis * Patients using the following medicines: hormonal anti not including Ketorolac; Dextran 40, ticlopidine and clopidogrel, systemic glucocorticoids, thrombolytic agents and anticoagulants and other antiplatelet agents, including antagonists of glycoprotein IIb / IIIa.