Impact of Three Different Gonadotrophin Regimes on Egg Donation Program

Instituto Valenciano de Infertilidad, IVI VALENCIA

Overview

Exploratory study assessing the effect of three gonadotrophin protocols on Controlled Ovarian Stimulation (COS) parameters and IVF outcome in oocyte donors undergoing GnRH analogue (long protocol). 1,028 donors were randomized in three groups: Group I (n= 346) only r-FSH, Group II (n= 333) only HP-hMG and Group III (n= 349) r-FSH plus HP-hMG. IVF outcome of 1,059 oocyte recipients was compared.

Study Type

INTERVENTIONAL

Conditions

Ovarian Stimulation

Interventions

r-FSHDRUG

HP-hMGDRUG

r-FSH plus HP-hMGDRUG

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 34 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy women 18-34 years of age * regular menstrual cycles * no family history of hereditary or chromosomal diseases * normal karyotype * BMI 18-29 Kg/m2 * negative screening for sexually transmitted diseases Exclusion Criteria: * women with PCOS were not included in this study

Locations (1)

IVI Valencia

Valencia, Spain

Outcomes

Primary Outcomes

The aim of this study was to verify whether different gonadotrophin regimes could affect controlled ovarian stimulation (COS) parameters and IVF outcome in an egg donation program.

Time frame: one year

Data from ClinicalTrials.gov

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