Metabolic Causes of Thrombosis in Type 2 Diabetes Mellitus

Inclusion Criteria * 16 Type 2 diabetic patients age 18 - 60 yrs * 16 Non-diabetic controls age 18-60 yrs * Body mass index \>20 kg/m2 * Female volunteers of childbearing potential: negative urine pregnancy test * Volunteers over 40 years old: an ECG with no clinically significant conduction or ischemic changes. * For those with type 2 diabetes: HBA1C \> 5.5% * For those with type 2 diabetes: C-peptide \>0.2 nmol, If C-peptide is abnormal or there is a clinical suspicion for type 1 diabetes, MODY or LADA, anti-islet cell and anti-GAD antibodies will be assessed to establish the diagnosis of type 2 diabetes vs. type 1/LADA/MODY. * PT (time) 12.8-14.6 seconds, PTT (time) 25-38 seconds Exclusion Criteria * Any current disease condition that alters carbohydrate metabolism (other than type 2 DM) and/or evidence for clinically significant cardiac disease * Uncontrolled hypertension * Pregnancy * Subjects unable to give voluntary informed consent * Subjects with history of pancreatitis * Subjects on anticoagulant drugs, anemic, or with known bleeding diseases * Subjects with history of GI bleeding requiring treatment * Tobacco Use * Subjects with history of heparin-induced thrombocytopenia or heparin allergy * Subjects with severe egg or legume (soybean) allergy * Abnormal results following screening tests and physical examination that is clinically significant: Medical history/Physical Exam Exclusion Criteria * Fever greater than 38 degrees C at screening or study initiation * Uncontrolled severe hypertension (i.e., blood pressure greater than 160/100) * Cardiac Abnormalities (e.g. Heart Failure, Arrhythmia, Cardiomyopathy, ischemic tachycardia, S-T segment deviations, etc.,) from history or ECG testing in subjects \> 40 years old. * Diagnosed Pneumonia * Hepatic Failure/Jaundice * Clinically significant coagulopathy * Renal Failure * Acute Cerebrovascular/ Neurological deficit Screening Laboratory Tests Exclusion Criteria according to protocol