Ligation of Intersphincteric Fistula Tract (LIFT) Procedure Versus Use of an Anal Fistula Plug for Anal Fistula Repair

Inclusion Criteria: * Male or female subjects 18 years of age or older. * Able to understand and provide informed consent or have a legally authorized representative capable of providing consent. * Has a documented diagnosis, confirmed by physical exam and/or endorectal ultrasound (if available), of a trans-sphincteric fistula tract determined to be of cryptoglandular origin (primary or recurrent). Exclusion Criteria: * History or suspicion of Inflammatory Bowel Disease (Crohn's or Ulcerative colitis). * History of connective tissue disease. * Rectovaginal fistula. * Presence of horseshoe fistula. * History of immunosuppression therapy/treatment within previous six months. * Presents of a proximal diversion and refractory fistula. * Any physical conditions, disease, or disorder that would exclude subject from being a candidate for elective surgery. * Known history of allergy to pork or pork products.