The purpose of the study is to determine whether the excretion of renal water- and salt-channels in the urine reflects the handling of water and salt in the kidneys, and whether the excretion can be used to monitor and/or predict the effects of treatment of certain heart or lung diseases.
The purpose of the study is to determine whether the excretion of renal water- and salt-channels (Aquaporin-2 and Epithelial Sodium Channels) in the urine accurately reflects the handling of water and salt in the distal tubules af the kidneys, and whether quantification of these channels in the urine is useful to monitor and/or predict the effects of pharmacologic or surgical treatment of Heart Failure and heart failure-related diseases (Aortic stenosis, acute and chronic ischemic heart disease or pulmonary hypertension)
Study Type
OBSERVATIONAL
Enrollment
150
Optimised, standard, evidence based heart failure therapy including the use of biventricular pacing.
Standard aortic valve replacement as per standard criteria in the department of thoracic surgery.
Standard percutaneous or surgical revascularisation in ACS.
Kolding Hospital
Kolding, Denmark
RECRUITINGDifferences in excretion of Aquaporin-2 in urine
Time frame: 6 months
Differences in excretion of Epithelial Sodium Channels in urine
Time frame: 6 months
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Standard percutaneous or surgical revascularisation