Inhalatorial Sedation in Patient With Subarachnoid Hemorrhage (SAH) Versus Conventional Intravenous Sedation

Azienda Ospedaliera San Gerardo di Monza13 enrolled

Overview

Recent study has shown that inhalatory sedation is a practicable, effective and not risky method in Intensive Care Unit. Sevoflurane effect on cerebral system have been described in previous studies: it causes an increasing of cerebral blood flow and a decrease of oxygen cerebral consumption. Clinical strategy for Subarachnoid Hemorrhage is orientated to increase cerebral blood flow to limit vasospasm phenomena after SAH. Scope of this study is to evaluate the Cerebral Blood Flow variation associated to Isoflurane sedation versus conventional sedation with propofol .

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Stroke Subarachnoid Hemorrhage

Interventions

Propofol(3-4 mg/kg/ora)administrated for 2 hours.

IsofluraneDRUG

Isoflurane inhalatorial administration for 2 hours at 0.8-1.0% Minimum Alveolar Concentration

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosis of aSAH * indication to DVE positioning * clinical indication to sedation and assisted ventilation * indication to ICP and CBF monitoring * age \> 18 Exclusion Criteria: * documented cranial hypertension (ICP\>18) not controller by liquor drainage * age \< 18.

Locations (1)

Azienda Ospedaliera San Gerardo

Monza, Monza, Italy

Outcomes

Primary Outcomes

Cerebral Blood Flow

Time frame: after 2 hours of drug administration

Data from ClinicalTrials.gov

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