Efficacy of Oral AB1010 in Adult Patients With Active Rheumatoid Arthritis

Inclusion Criteria: 1. Meet American College of Rheumatology (ACR) criteria for RA 2. Have active RA 3. ACR functional class I-III 4. Disease onset at \> 16 years of age 5. Disease duration of at least 6 months 6. Failure to one DMARD including methotrexate and anti-TNF alpha Exclusion Criteria: 1. Pregnant or breastfeeding women 2. Inadequate bone marrow function 3. Current use of a DMARD within 4 weeks (or 5 half-lives, whichever is longer) of screening except for leflunomide which requires a specific wash-out 4. Any previous use of recombinant IL1-Ra 5. Current use of more than 1 non steroidal anti-inflammatory drug (NSAID) or change of dose of the NSAID within 4 weeks of baseline or NSAID use greater than the maximum recommended dose 6. Within 4 weeks before baseline, use of more than 10 mg/day of prednisone or equivalent or change in the dose of prednisone or equivalent, or having intra-articular corticosteroid injection or bolus intramuscular or intravenous treatment with corticosteroids (\>20 mg prednisone or equivalent