Efficacy of AB1010 in Patients With Systemic Indolent Mastocytosis

Inclusion Criteria: 1. Patients with documented Indolent systemic mastocytosis with handicap (ISMwh) having at least 2 infiltrated\* organs (skin and /or bone-marrow and/or internal organ). 2. Bone-marrow, or skin or internal biopsy-documented mastocytosis and evaluable disease. 3. The absence of an activating point mutation in the phosphotransferase domain of c-Kit such as D816V c-Kit mutation in at least one of the two infiltrated organs: bone marrow and/or skin and/or other tissue. 4. Handicap defined as at least one of the following handicaps: * a number of flush per day ≥ 1 , * a pruritus score ≥ 9 , * a number of stools per day ≥ 4 , * a Pollakyuria (on a per day basis) ≥ 8 , * a QLQ-C30 score ≥ 83 , * a Hamilton rating scale for depression ≥ 12 Exclusion Criteria: 1. Performance status \> 2 (ECOG). 2. Inadequate organ function, except if the abnormalities are due to involvement by mast cells