Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle Regeneration

Bispebjerg Hospital32 enrolled

Overview

The purpose of this study is to determine the influence of non-steroidal anti-inflammatory drugs (NSAIDs) on muscle regeneration. The investigators' hypothesis is that ingestion of NSAID will delay or impair muscle regeneration.

The model employed to induce muscle damage is electrical stimulation. Muscle biopsies will be examined to follow the response of satellite cells and muscle regeneration. Study participants will be randomly assigned to a placebo or NSAID group in a double-blinded manner.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Muscle Damage

Interventions

NSAIDDRUG

Effect of NSAID ingestion on muscle regeneration

placeboDRUG

receive placebo

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * male * healthy * does not exercise regularly Exclusion Criteria: * displays contraindications for taking NSAID * well-trained

Locations (1)

Bispebjerg Hospital

Copenhagen, NV, Denmark

Outcomes

Primary Outcomes

Muscle regeneration

Time frame: 1 month

Secondary Outcomes

Muscle strength

Time frame: 1 month

Data from ClinicalTrials.gov

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