Effect of Preoperative Chemoradiotherapy on Exercise Capacity as Measured by Cardiopulmonary Exercise Testing

Imperial College London40 enrolled

Overview

This study will investigate the effect of preoperative chemoradiotherapy on exercise capacity as measured by cardiopulmonary exercise testing in patients with colorectal cancer.

Chemoradiotherapy is associated with adverse effects. Patients with certain colorectal cancers undergo chemoradiotherapy prior to surgical resection. We intend to assess patient exercise capacity before and after chemoradiotherapy to assess whether this deteriorates. If there is a deleterious effect, this may affect operative outcome.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Colorectal Cancer

Interventions

Cardiopulmonary exercise testingOTHER

Cardiopulmonary exercise testing involves cycling on an exercise bicycle whilst oxygen consumption and carbon dioxide generation are measured from expired gases. This is used to calculate patient fitness from their peak oxygen consumption and their anaerobic threshold.

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age greater than 65 * Colorectal cancer requiring preoperative chemoradiotherapy Exclusion Criteria: * Inability to walk, or exercise on a bicycle or treadmill * Inability to understand instructions for CPET testing * ASA grade 4 or 5 (indicating severe cardiovascular co-morbidity and not expected to survive surgery) * Contraindications to Exercise Testing * Myocardial infarction occurring 10 days or less before CPX testing * Symptomatic arrythmias * Left Main Stem coronary disease of \>50% * Severe hypertension (SBP\>180mmHg) * Resting SpO2 \<85% * Acute cardiac inflammatory conditions (myocarditis, pericarditis) * Unstable angina with symptoms within 4 days * Dissecting aneurysm of aorta * Acute pyrexial illness * Thyrotoxicosis * Syncopal episodes * Lower limb thrombosis (arterial or venous)

Locations (1)

Imperial NHS Trust, St Mary's Hospital, Praed Street

London, United Kingdom

Outcomes

Primary Outcomes

Change of Anaerobic threshold of 1.5ml/min/kg or more

Time frame: 6 weeks

Secondary Outcomes

Operative outcome

Time frame: 6-10 weeks

Data from ClinicalTrials.gov

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