No accurate, inexpensive and non-invasive test for gastric cancer screening is currently available. The investigators' recent study identified a1-antitrypsin and other proteins as potential biomarkers of gastric cancer in gastric juice. The aim of this study was to develop a novel non-invasive modality for detecting gastric cancer by measurement of biomarkers in gastric juice.
Patients and methods: The study consisted of two parts: (1) investigating the differences in gastric juice biomarker concentrations between gastric cancer patients and controls, and (2) screening gastric cancer using string test to obtain gastric juice followed by immunoassay for biomarker concentration.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
76
biomarker in gastric juice, i.e., alpha 1-antitrypsin, CEA
biomarker in gastric juice, e.g., alpha 1-antitrypsin
Kaohsiung Veterans General Hospital
Kaohsiung City, Kaohsiung, Taiwan
Kaohsiung Veterans General Hospital
Kaohsiung City, Taiwan
Number of Participants With Accurate Diagnosis for Gastric Cancer
Normal subject group: number of the subjects with normal alpha 1-antitrypsin level in gastric juice Gastric cancer group: number of the subjects with elevated alpha 1-antitrypsin level in gastric juice
Time frame: 2 months
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