Carvedilol (25 mg) in 24 Fed, Healthy, Adult Subjects

Inclusion Criteria: * Sex: Male of Female; similar proportions of each preferred. * Age: At least 18 years. * Weight: Minimum of 120 pounds and a BMI (body mass index) of less than 30. Exclusion Criteria: * Subjects not complying with the above inclusion criteria must be excluded from the study. * In addition, any one of the conditions listed below will exclude a subject from the study. * History of treatment for alcoholism, substance abuse, or drug abuse within the past 24 months * History of malignancy, stroke, diabetes, cardiac, renal or liver disease, or other serious illness. * History of treatment for any gastrointestinal disorder within the past five (5) years. * History of, or presence of, asthma * History of peripheral vascular disease * History of heart failure * History of pre-existing cardiac arrythmias associated with tachycardia * History of severe sensitivity to allergens, requiring urgent medical treatment. * Females who are pregnant or lactating * History of hypersensitivity to carvedilol, or any beta adrenergic blocking drug. * Conditions upon screening which might contraindicate or require that caution be used in the administration of carvedilol, including: * sitting systolic blood pressure below 100 mmHg, or diastolic pressure below 60 mmHg. * Heart rate less than 60 beats per minute after a 5-minute rest in a seated position. * Inability to read and/or sign the consent form. * Treatment with any other investigational drug during the four (4) weeks prior to the initial dosing for this study. * Subjects who smoke or use tobacco products or are currently using nicotine products (patches, gums,etc.) Ninety (90) days abstinence is required. * subjects who have donated blood within four (4) weeks prior to the initial dosing for this study.