Autonomic Nervous System Alteration Induce by Sepsis: Assessment and Prognosis Impact

University Hospital, Grenoble13 enrolled

Overview

Severe sepsis and septic shock are causes of admission in intensive care units.Modification of natriuretic peptid including NT-proBNP and cardiac autonomic nervous system alteration are reported in sepsis shock and severe sepsis and seems to link to patient prognosis admitted to intensive care units.

Our principal aim is to characterize modulation of cardiac sympathic nervous system in sepsis through the study of sinusal change and myocardiac fixing of MIBG. The second aim is 1)to assess links between alteration of cardiac sympathic nervous system and NT-PRoBNP variations in sepsis and 2)To know prognostic impact in sympathic nervous system compare to NTproBNP.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Septic Shock Severe Sepsis

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patient over 18 years admitted in intensive care unit and having severe sepsis criteria or septic shock documented or suspected define as Bone Criteria * hemodynamically stable situation * sinusal rhythm * Patient for social security Exclusion Criteria: * Minors * Patient under guardianship or trusteeship * pregnant or lactating women * diabetic * cardiomyopathy known and/or treated or detect in admission * electro-systolic process permanent or transitory * neurological history or degenerative pathology * chronic respiratory insufficiency * Chronic renal insufficiency

Locations (1)

University Hospital Grenoble

Grenoble, France

Outcomes

Primary Outcomes

Sinusal variability analysis and myocardic fixation of MIBG performed in 48 hours post admission

Time frame: 48 hours post admission

Secondary Outcomes

plasmatic measure of NT-ProBNP and catecholamine at admission, day 2 and last day of hospitalisation

Time frame: 30 days

Data from ClinicalTrials.gov

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