In transposition patients after atrial switch operation, the morphological right ventricle serves as the systemic ventricle. These patients often develop signs of heart failure. It is not known, whether physical training can safely be recommended in these patients- like heart failure guidelines recommend training in patients with normal anatomy. Furthermore it is not known, whether these TGA-patients benefit from training with respect to cardiopulmonary exercise capacity.
This is a randomized, controlled, prospective trial on the safety of physical training in TGA patients after atrial switch operation. In transposition patients after atrial switch operation, the morphological right ventricle serves as the systemic ventricle. These patients often develop signs of heart failure. It is not known, whether physical training can safely be recommended in these patients- like heart failure guidelines recommend training in patients with normal anatomy. Furthermore it is not known, whether these TGA-patients benefit from training with respect to cardiopulmonary exercise capacity. Primary endpoints are Systemic Ventricle Ejection Fraction and Volumes, Exercise Capacity. Secondary endpoints are Echo Diastolic Function, as well as laboratory markers of heart failure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
48
Controlled home ergometer training
Hannover Medical School
Hanover, Germany
Cardiac MRI Right Ventricular Ejection Fraction
Time frame: 6 and 12 months
Cardiopulmonary exercise capacity
Time frame: 6 and 12 months
laboratory markers of heart failure
Time frame: 6 and 12 months
Diastolic RV and LV function
Time frame: 6 and 12 months
Right ventricular volumes
Time frame: 6 and 12 months
Right ventricular mass
Time frame: 6 and 12 months
NYHA-class
Time frame: 6 and 12 months
quality of life questionnaire
Time frame: 6 and 12 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.