Study Evaluating the Safety, Pharmacokinetics (PK), and Pharmacodynamices (PD) of HSD-016

Inclusion criteria: 1. Men or women of nonchildbearing potential aged 18 to 50 years. 2. Healthy as determined by investigator on the basis of medical history and physical examination, laboratory test results, and 12-lead ECG. 3. Nonsmoker or smoker of fewer than 10 cigarettes per day. Exclusion criteria: 1. No history of thyroid abnormalities. 2. No presence or history of any disorder that may prevent the successful completion of the study. 3. No history of drug abuse. 4. No use of any systemic steroids for 3 months. 5. No history of claustrophobia.