Markers of Airway Inflammation in BAL Fluid From Children With Asthma

National Jewish Health103 enrolled

Overview

The study compares the biochemical markers in bronchoalveolar lavage samples from asthmatic children to those markers found in non-asthmatic children with other respiratory diseases. The investigators hypothesize that certain markers will be associated specifically with asthma.

Study Type

OBSERVATIONAL

Enrollment

103

Conditions

Asthma

Eligibility

Sex: ALLMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years of age or younger * Scheduled for bronchoscopy at National Jewish Health for persistent asthma, persistent, poorly controlled wheezing, chronic cough, GERD, atelectasis, bronchopulmonary dysplasia, infection. * Consent and assent from parent and patient \[if appropriate\]. Exclusion Criteria: * Unwillingness to consent/assent to retrieval of BAL fluid for research analysis.

Locations (1)

National Jewish Health

Denver, Colorado, United States

Outcomes

Primary Outcomes

The measurement of levels of lipopolysaccharides [LPS], which mediates airway inflammation, in bronchoalveolar lavage [BAL] fluid from children with asthma and comparison to LPS levels in children with non-asthma respiratory diseases

Time frame: Single time point

Secondary Outcomes

Characterization of the inflammatory cytokine and chemokine profiles in bronchoalveolar lavage [BAL] fluid in children with asthma and comparison to the profile for children with non-asthma respiratory diseases.

Time frame: Single time point

Data from ClinicalTrials.gov

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