Phase IIa Safety and Efficacy Study of SRD174 Cream in Patients With AD-associated Pruritus

Inclusion Criteria: * Males and females aged 18 years and over moderate to severe AD pruritus * Written signed and dated informed consent * Satisfactory medical assessment with no clinically relevant abnormalities Exclusion Criteria: * Subject with active and pruritic AD covering a body surface area (BSA) \> 20% * Subject with severe AD defined as an IGA score of 4 * Subject with current or recurrent skin disease (except AD) that could affect the site of application of action, absorption or disposition of the investigational product, or clinical, laboratory assessments. * Subjects with unstable or uncontrolled medical conditions that could require intensive treatment during the course of the study. * Subject with known or suspected intolerance or hypersensitivity to the Investigational products or any of the stated ingredients. * Subject who has a medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or investigational product administration or may interfere with interpretation of trial results and, in the judgment if the investigator, would make the subject inappropriate for entry into this trial.