Safety and Efficacy Study of Association Between Tretinoin and Clindamycin on the Treatment of Acne Mild and Moderate

Inclusion Criteria: * Individuals of both sexes with age greater than or equal to 12 years * Subjects diagnosed with acne vulgaris in the face, except for the nasal area, range from mild to moderate, with the following requirements. * Mild acne = presence of fewer than 20 comedones or less than 15 lesions, inflammatory lesions or a total of less than 30 injuries. * Moderate acne = presence of 20 the 100 comedones or of 15 the 50 inflamatory lesions or a total of 30 the 125 lesions, with not more than lesions small nodule until 5,0 mm. * Ensure that the existing injuries were not submitted any treatment for acne, topical or systemic, within the last 30 days. * Be able to properly follow the determinations of the Protocol. * Has provided a written voluntary consent to participate in the study, by signing the informed consent, before being subjected to any procedure. * Under 18 years old, be accompanied by legal guardian in the process of obtaining the informed consent. * Be mentally able to provide consent and be fulfilling all the requirements of the study. Exclusion Criteria: * Pregnant women or in periods of lactation. * Women of childbearing age and sexual activity with not using safe contraceptive method, such as oral contraceptives, implantable, injectable or intra-uterine, introduced for at least 120 days. * Women who are using oral contraceptives containing the hormone combination for acetate ciprosterone and etinolestradiol, association of drospirenone and ethinyl estradiol, or desogestrel. * Clinical evidence or history of immunodeficiency. * Any use of immunosuppressive drug and/or immunomodulating over the past 3 months, topical or systemic. * Concurrent use of fotossentetizadores, neuromuscular blockers, medications that exacerbate the acne, blockers (filters) with solar alcoholic vehicle, spironolactone, flutamide or zinc salts. * Prior use of systemic retinoid. * Presence of acne medication and/or cosmetic. * History of systemic metabolic disorder that can interfere with the integrity of the skin. * History of inflammatory disease, intestinal or regional enteritis and/or symptoms similar. * History of joy to any of the components of the formula (active principle or carrier). * History of abuse of alcohol and/or illegal drugs. * History of non-adherence to medical treatment earlier. * Any clinical observation made by the investigator that prohibits participation in the study of the subject.