Study aimed to compare the effect of grape seed extract and ascorbic acid in oxidative stress induced by on pump coronary artery by pass grafting surgery.
This study aimed to compare the effect of grape seed extract and ascorbic acid in oxidative stress induced by on pump coronary artery by pass grafting surgery. There are three groups in the study. 75 candidate of coronary artery by pass grafting surgery were assigned random allocation on the groups (25 in each group). 1. Control 2. GSE (100 mg/6h - PO, 24h before surgery) 3. Vit C (25 mg/kg in pump circulation during surgery)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
72
grape seed extract (100 mg/6h), PO
Vit C 25 mg/ kg
Cardiovascular Research Center
Tabriz, East Azerbaijan Province, Iran
LVEF
Time frame: Before and after CABG
Total Antioxidant Capacity (TAC)
Time frame: Before ischemia, after ischemia, after reperfusion
MDA
Time frame: Before, middle and after CABG
GTX
Time frame: Before ischemia, after ischemia, after reperfusion
SOD
Time frame: Before ischemia, after ischemia, after reperfusion
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