Retinal Function in Diabetic Patients Without Retinopathy

Assistance Publique - Hôpitaux de Paris56 enrolled

Overview

The primary purpose was to assess, in diabetic patients without diabetic retinopathy and control subjects, color vision, contrast sensitivity, electroretinography, and flicker-induced vasodilatation using the Dynamic Vessel Analyzer, in order to specify the earliest impaired retinal cells in diabetes, and gain more insight into diabetic retinopathy pathogenesis.

Type 1 and type 2 diabetic patients with no diabetic retinopathy and no hypertension were compared with sex and age-matched control subjects. Color vision was tested with the desaturated LANTHONY 15-Hue test. Contrast sensitivity was assessed with the Pelli-Robson contrast sensitivity test. Pattern-electroretinogram, Ganzfeld full-field electroretinogram and multifocal electroretinogram were recorded according to the International Society for Clinical Electrophysiology of Vision (ISCEV). Flicker-induced vasodilatation in retinal arteries and veins was assessed using the Dynamic Vessel Analyzer.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2

Eligibility

Sex: ALLMin age: 20 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * For diabetic patients : * age between 20 and 55 * type 1 or type 2 diabetes mellitus * diabetes duration of more than 5 years * no diabetic retinopathy on fundus examination or fundus photographs * For control subjects : * sex and age matching with the diabetic patients * no diabetes, no familial or personal history of elevated blood sugar Exclusion Criteria: \*For both diabetic patients and control subjects : * presence of cataract or history of cataract surgery * intraocular pressure of more than 21 mmHg * abnormal score on the Ishihara test * other ocular disease * ametropia more than 3 diopters, anisometropia more than 1 diopter, astigmatism more than 1 diopter * systemic hypertension (defined as systolic blood pressure \> 140 mmHg, diastolic blood pressure \> 90 mmHg) * treatment with vasoactive drugs * tobacco consumption of more than 20 cigarettes a day

Locations (1)

Hopital Lariboisiere

Paris, France

Data from ClinicalTrials.gov

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