A Clinical Study to Investigate if Transfusion of Patients Own Shed Blood Improves the Immunological Status in Comparison to Transfusion of Donor Blood ("Bank Blood")

Inclusion Criteria: * Provision of informed consent * Male and female patients aged 18 years and over scheduled for total knee replacement * Subjects classified as ASA Physical Status Classification System class P1, P2 or P3 according to the American Society of Anaesthesiology Exclusion Criteria: * Involvement in the planning and conduct of the study (applies to both Astra Tech staff or staff at the study site) * Pre-operatively haemoglobin below normal range as judged by the investigator * Previous enrolment or randomisation to treatment in the present study * Expected or confirmed participation in another clinical study during the study period * Severe non-compliance to protocol as judged by the investigator and/or Astra Tech * Current symptoms of haemophilia * History of or presence of malignant disease with propensity for systemic spread during the last 5 years * Current or expected use of cytotoxic drugs * Current untreated anaemia (e.g. sickle cell anaemia) as deemed by investigator * Use of pre-donation * Use of recombinant erythropoetin * Use of other autologous blood transfusion than that with Bellovac ABT, e.g. washed and centrifuged blood like CellSaver