PAF-HEFT (Permanent Atrial Fibrillation in Heart Failure Trial)

Phase 4TerminatedNCT00839566

Medtronic Cardiac Rhythm and Heart Failure12 enrolled

Overview

Examination of CRT efficacy in patients with progressive heart failure and atrial fibrillation at the same time

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Atrial Fibrillation Heart Failure

Interventions

AblationPROCEDURE

AV-node ablation

Rate ControlOTHER

Rate control by drug

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * LVEF \<35% * QRS time ≥150ms LBB * NYHA classification ≥ NYHA III * permanent (\> 6 months) Atrial Fibrillation * sinus rhythm (control group) * Condition after Implantation of a Medtronic CRT device * written informed consent Exclusion Criteria: * exchange of the current CRT device * mitral incompetence (2. degree) * no compliance * participation in another study * pregnancy * patients with AV node * patients after heart transplant or those who are on the transplant list

Locations (1)

Professor Dr. med. Christian Perings

Lünen, Germany

Outcomes

Primary Outcomes

End systolic left ventricular diameter

Time frame: 12 months

Secondary Outcomes

NYHA-Class, Echo-parameters, ECG-parameters, VO2 max,6 minutes hallwalk-test

Time frame: 12 months

Data from ClinicalTrials.gov

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