Dose Escalation Study of EC D-3263 HCl in Advanced Solid Tumors

Inclusion Criteria: * histologically or cytologically confirmed advanced solid tumor malignancy which is either refractory to standard therapy or for which no standard therapy exists * measurable or evaluable disease * \>= 18 years of age * ECOG of 0, 1 or 2 * no treatement with chemotherapy, radiotherapy or other systemic therapy (excluding depot LHRH agonist or antagonist for subjects with prostate cancer) for the treatment of his or her tumor with in 28 days prior to receipt of EC D-3263 HCl Exclusion Criteria: * Clinically significant coronary artery disease or conduction system abnormality * Coagulation disorder * Active infection requiring the use of systemic antimicrobial medications within seven days prior to receipt of EC D-3263 HCl * Any major surgery within 28 days prior to receipt of EC D-3263 HCl