A Study of Hydroxypropyl Guar Galactomannan 0.25% (HPGG) Versus Vehicle in Dry Eye Patients

Inclusion Criteria: * Must read, sign, and date an informed consent document and HIPAA privacy document. * Diagnosis of dry eye at Visit 1 (Day 0). * Able and willing to follow study instructions. * Best corrected visual acuity (BCVA) of 0.6 logMAR or better in each eye as assessed using an ETDRS chart at Visit 1. * Other protocol-defined inclusion criteria may apply. Exclusion Criteria: * Diagnosis of Sjogren's syndrome (or suspected to have Sjogren's syndrome). * History or evidence of ocular or intraocular surgery in either eye within the previous year. * History or evidence of serious ocular trauma in either eye within the previous 6 months. * History or evidence of corneal transplant or transplant variant procedures. * History of intolerance or hypersensitivity to any component of the study medications. * History of glaucoma or current ocular hypertension in either eye, or treatment for either condition within 6 months prior to Visit 1. * History or evidence of corneal conditions, other than dry eye, that may affect the corneal structure. * Use of any concomitant topical ocular medications including artificial tears during the study period. * Females of childbearing potential if breastfeeding, unwilling to undergo urine pregnancy test at screening and upon exiting the study, have a positive urine pregnancy test at screening, intend to become pregnant during the study, or do not agree to use adequate birth control methods for the duration of the study. * Use of RESTASIS® 0.05% or an ocular steroid within 30 days of Visit 1. * Use of systemic medications that have not been stable for 30 days prior to Visit 1. * Any ocular condition that may preclude the safe administration of the test article. * Unwilling to discontinue contact lens wear at least 4 weeks prior to Visit 1, and during the study period. * Use of punctal plugs or punctal cautery. * Use of lid scrubs/warm compresses within 14 days of Visit 1. * Other protocol-defined exclusion criteria may apply.