Chlorhexidine & Pneumonia in Nursing Home Residents

University of Louisville75 enrolled

Overview

The purpose of this study is determine if topical oral application of a chlorhexidine antimicrobial spray will significantly reduce pneumonia and respiratory infections, and improve oral health compared to a placebo solution in nursing home residents.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Pneumonia Respiratory Infection

Interventions

chlorhexidineDRUG

0.12% chlorhexidine mouthwash spray, \~1.3 ml, twice a day.

Placebo mouthwashDRUG

Placebo mouthwash spray application of \~1.3 ml twice a day.

Eligibility

Sex: ALLMin age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Participants must be at least 65 years old. 2. Be dependent in 2 or more Activities of Daily Living as noted on the nursing home resident's Minimum Data Set - One must be ADL J- Personal Hygiene. 3. Have natural teeth and/or wear complete or partial dentures. 4. Expected to be a resident in a nursing home for two years. Exclusion Criteria: 1. Existing pneumonia. 2. History of chlorhexidine reaction or allergy and/or multiple medication or substance allergies. 3. Receiving chlorhexidine oral application at enrollment as prescribed by physician or dentist.

Locations (1)

University of Louisville

Louisville, Kentucky, United States

Outcomes

Primary Outcomes

Pneumonia

Time frame: 12 months

Secondary Outcomes

Respiratory pathogens

Time frame: 12 months

Plaque and Gingival Indices

Time frame: 12 months

Data from ClinicalTrials.gov

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