Sleep and Obesity in Teenagers

Hospices Civils de Lyon41 enrolled

Overview

This study aims to investigate 1. whether sleep extension results in improvements of endocrine and metabolic markers of obesity and diabetes in obese teenagers, 2. the relationship between habitual sleep quality and duration and markers of obesity and diabetes in lean and obese teenagers.

Inclusion of 13 obese teens. Duration : 1 week of screening period + 1 week of intervention: habitual/extended sleep length + 1 week of intervention: extended/habitual sleep length. A wash out period of at least 3 months will be required between the two interventions. Inclusion of 13 non obese healthy teen controls for measuring reference sleep duration and physiology level. Duration for these group: 1 week of screening period + 1 week of habitual sleep length

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Obesity

Interventions

habitual sleep length period + extended sleep length periodBEHAVIORAL

On obese group, realisation of an habitual sleep length period followed by an extended sleep length period

extended sleep length period + habitual sleep length periodBEHAVIORAL

On obese group, realisation of an extended sleep length period followed by an habitual sleep length period

Eligibility

Sex: ALLMin age: 15 YearsMax age: 17 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male or female over 15 and under 18 year-old. * Teenager with normal weight or stage 2 obesity, according to international standards (WHO) * Post-pubescent teenagers (menstruation for girls and stage 4-5 of Tanner scale for boys) * Teens with an social security * Girl with negative urine pregnancy test Exclusion Criteria: * Active smoker (interview) * Refuse consent (parents or teen) * Addiction such as coffee, drug…(interview) * Medicinal treatment that may influence sleep and measured variables (interview) * Obesity diagnosis : less than 1 year (interview) * Concomitant diseases : renal or hepatic failure, iron deficit, diabetes, endocrinal pathology, hypertension * Anxiety (Spielberg\>56), , depression (CDI\>19). * Mild or sever insomnia (ISI\>15), poor sleep quality (PSQI \>10), excessive sleepiness (Epworth\>10, sleep) length\>9 hour), extreme circadian typology (Horne et Ostberg from 70 to 86 or 16 to 30) * Blood sample taken within the last two months before inclusion * Mild or severe sleep apnoea or excessive leg movements according to EEG analysis

Locations (1)

Hospices Civils de Lyon

Lyon, France

Outcomes

Primary Outcomes

The influence of sleep extension on leptin level for the obese teens group.

Time frame: at the end of each sleep experimental period

Secondary Outcomes

Difference between the two groups (obese vs non-obese) regarding sleep length and delta waves activity.

Time frame: during each sleep experimental period (habitual or extended)

Study the correlation between delta waves activity and habitual sleep length

Time frame: During each sleep experimental period

Study the correlation between delta waves activity and psychological, behavioural, anthropometric and physiological markers of obesity and its co morbidities

Time frame: During each sleep experimental period

Data from ClinicalTrials.gov

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