Comparison of 7-day and 14-day Bismuth Based Quadruple Therapy for Secondary Helicobacter Pylori Eradication

Asan Medical Center199 enrolled

Overview

At present, triple therapy are recommended by various guidelines for the treatment of Helicobacter pylori (H. pylori) infection. Recent studies have shown worldwide high treatment failure rates with one week first line clarithromycin based triple therapy necessitating salvage strategy to eradicate H. pylori in primary treatment failure. However, the exact duration of bismuth based second line treatment is not determined. Therefore, the investigators performed this study to evaluate the eradication rate of 1 or 2-week quadruple regimen as a second-line therapy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

199

Conditions

Helicobacter Infection

Interventions

pantoprazole

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * H. pylori infection * Aged between 18-80 years * Are willing to received eradication therapy for H. pylori Exclusion Criteria: * Children and teenagers aged less than 18 years or over 80 years * Previous eradication therapy for H. pylori * History of gastrectomy * Previous allergic reaction to antibiotics * Use of prompt pump inhibitors and antibiotics in the recent 4 weeks * Active upper GI bleeding in the recent 1 week * Contraindication to treatment drugs * Pregnant or lactating women * Severe concurrent disease or malignancy

Outcomes

Primary Outcomes

Whether the two week group yield a higher eradication rate comparing to the one week group.

Time frame: At least four week after completion of treatment

Secondary Outcomes

side effect

Time frame: four weeks after completion of medication