The objective of this study is to compare the reduction in office seated systolic blood pressure (BP) following a 8 weeks regimen of ramipril 5mg plus felodipine 5mg versus ramipril 10mg. To compare the response rate (defined as office systolic blood pressure (SBP) / Diastolic blood pressure (DBP) reduce more than 10mmHg from baseline), and BP controlled rate (defined as SBP\<140mmHg and/or DBP\<90mmHg) and as SBP \< 130 mmHg and /or DBP \< 80 mmHg in diabetes,chronic kidney disease, known Coronary Arterial Disease (CAD) or CAD equivalent, or 10-year Framingham risk score \> 10%. To ascertain the safety and tolerability of ramipril/felodipine versus ramipril in Taiwanese population. To compare compliance with fixed dose combination of ramipril/felodipine versus ramipril treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
49
Ramipril 5mg + Felodipine 5mg once a day
10 mg once a day
5mg once a day
Sanofi-Aventis Administrative Office
Taipei, Taiwan
Seated SBP at office
Time frame: After 8-week treatment
Seated DBP at office
Time frame: After 4 and 8-week treatment
Seated SBP at office
Time frame: After 4-week treatment
Response rate
Time frame: After 4 and 8-week treatment
BP controlled rate
Time frame: After 4 and 8-week treatment
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