Endocardial Stem Cells Approach Efficacy

Inclusion Criteria: * Men and women who are not of childbearing potential * Age 21-75 years. * Patients with CAD, NYHA and CCS angina III-IV functional class * LVEF less than 35% measured by echocardiography or SPECT within three months of study entry * Unsuitable for initial or repeated conventional revascularization (CABG or PCI) Exclusion Criteria: * Failure to provide informed consent. * Plan for PCI or CABG. * Non-cardiac illness with a life expectancy of less than 3 year. * Conditions/circumstances likely to lead to poor treatment adherence (e.g., history of poor compliance, alcohol or drug dependency, psychiatric illness, no fixed abode). * Previous heart, kidney, liver, or lung transplantation. * Current participation in another clinical trial in which a patient is taking an investigational drug or receiving an investigational medical device. * Recent acute myocardial infarction (AMI) within 90 days of study entry * Successful coronary revascularization (СABG or PCI) within 12 months of study enrollment * History of moderate to severe aortic stenosis or prosthetic aortic valve * Permanent atrial fibrillation * Thrombosis in LV, based on echocardiography data