Post-Operative Use of Salt Poor Albumin Solution in Resuscitation of Orthotopic Liver Transplant

McGill University Health Centre/Research Institute of the McGill University Health Centre100 enrolled

Overview

The purpose of the study is to examine if outcome after liver transplantation is improved by using albumin infusion post-transplantation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

100

Conditions

Liver Transplantation

Interventions

Albumin infusion (25% albumin)DRUG

Patients in this arm will receive albumin infusions 3 times a day for the first 7 days post-operative

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years or older * Canadian Transplant status 1 or 2 * Patients at the Royal Victoria Hospital, Montreal, Canada Exclusion Criteria: * Emergency liver transplant (canadian transplant status 3 or 4) * patients who have received more than 300cc of albumin within 48 hours prior to transplant * patients who underwent previous solid organ transplant * multi-organs transplant recipients * patients who had previous adverse reaction to human albumin solution * patients who have religious restriction to receiving human blood products. * patients or surrogate unable to give consent to the study

Locations (1)

Royal Victoria Hospital

Montreal, Quebec, Canada

Outcomes

Primary Outcomes

Post Transplant Liver Function Test (PTLFT)

Time frame: Post-operative Day1 through 7 and Day 15,30, 45

Secondary Outcomes

Functional 6 minutes walking test

Time frame: Post-operative

Calculated creatinine clearance

Time frame: Post-operative day 1, 7, 15, 30, 45

Length of hospital stay

Time frame: post-operative

ICU length of stay

Time frame: post-operative

duration of mechanical ventilation

Time frame: post-operative

duration of renal replacement therapy

Time frame: postoperative

ICU readmission rate

Time frame: post-operative

reintubation rate

Time frame: post-operative

Post-operative infection rate

Time frame: Post-operative

Need to re-operation unrelated to technical complication

Time frame: post-operative

Functional hand grip Jamar Dynamometer hand grip test

Time frame: Post-op day 7, 15, 30

Central Contacts

Mathieu Rousseau, MD

CONTACT

514.567.0292 mathieu.rousseau@mail.mcgill.ca

Mazen Hassanain, MD

CONTACT

514.934.1934 mazen.hassanain@muhc.mcgill.ca

Data from ClinicalTrials.gov

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