Trial of Simvastatin in Amnestic Mild Cognitive Impairment (MCI) Patients

Inclusion Criteria: 1. Self and informant report of gradually increasing memory impairment for at least six months. 2. Objective memory impairment 3. Intact basic activities of daily living 4. Preserved general cognitive function, not demented 5. Absence of a detectable cause of memory disorder 6. Age 55 to 90. 7. Females without childbearing potential 8. A total cholesterol ≥90 mg/dl 9. LDL-cholesterol ≥ 160 mg/dl and ≤ 3 risk factors or ≥ 190 mg/dl and ≤ 2 risk factors including age 10. Informed consent (according german medicinal products act, AMG §40 (1) 3b) 11. No participation in other clinical trials 2 months before and after participation in this study 12. Probands should only recruited for the clinical trial, when they are able to perform the informed consent; due to worsening of "memory function" in the course of the clinical trial, probands should not longer participate the clinical trial, when they is evidence, that participants were not longer able to give full informed consent. Exclusion Criteria: 1. Hypersensitivity against Simvastatin, active liver disease or lasting increase of serum transaminases for unclear reason 2. Unstable medical, neurological or psychiatric disease 3. Lack of a spouse or a close relative 4. Use of a registered anti-dementia drug or a nootropic 5. Chronic use of anti-inflammatory drugs 6. History of stroke or myocardial infarction 7. LDL-cholesterol 130-160 mg/dl and \> 3 risk factors or 160-190 mg/dl and \> 2 risk factors including age. 8. LDL-cholesterol \>190 mg/dl 9. Comedication with Diltiazem, Verapamil, Amiodarone, Itraconazole, Ketoconazole, Erythromycin, Clarithromycin, Telithromycin, Ciclosporin, Gemfibrozil, Nefazodone, HIV-protease inhibitors, Benzodiazepines, Tricyclic antipsychotics or other anticholinergic drugs 10. Comedication of other statins in high doses; low doses equivalent to 20 mg Simvastatin are allowed if taken for max. 2 years before randomization