Food and Relative Bioavailability Study

Inclusion Criteria: * Healthy male or female between 18 and 65 years of age inclusive. * A female subject is eligible to participate if she is of either non-childbearing potential or child-bearing potential and agrees to use one of the contraception methods * No co-morbid Psychiatric Disorders as defined using the Mini International Neuropsychiatric Interview (M.I.N.I) scale. * A 12-lead ECG at screening showed no abnormalities that in the opinion of the Principal Investigator will compromise safety in this study. \-- Body weight ≥ 50 kg and BMI within the range 19.0 - 29.9 kg/m2 (inclusive). * Capable of giving written informed consent Exclusion Criteria: * As a result of any of the medical interview, physical examination or screening investigations the Physician Responsible considers the subject unfit for the study. * The subject has a history of a drug or other allergy which in the opinion of the Physician Responsible contraindicates the participation in the study. * Subjects with an unstable medical disorder or a disorder that would likely interfere with the action, absorption, distribution, metabolism or excretion of orvepitant, may pose a safety concern, or interfere with accurate assessment of safety. * The subject has a current or recent (within six months) documented gastrointestinal disease; a history of malabsorption, oesophageal reflux, or irritable bowel syndrome; frequent (more than once a week) occurrence of heartburn, or any surgical intervention (e.g. cholecystectomy) which would be expected to influence the absorption of drugs. * History of psychiatric illness * Any history of a clinically significant abnormality of the neurological system (including dementia and other cognitive disorders or significant head injury) or any history of seizure (excluding febrile seizure). * Subject is consuming alcool or tobacco * Subject is positive to Hepatitis B, C or HIV