Medication-related non-adherence increases the risk of rejections and associated graft loss after solid organ transplantation. A randomized controlled intervention will use adherence enhancing strategies out of a larger sample of 300 heart transplant recipients. Non-Adherence will be assessed by patients' self-report and based on immunosuppression level. All non-adherent patients will be randomly designed to either intervention or control group. Multi-module interventions include patient education, electronic medication event monitoring, and a combined behavior and symptom management. Longitudinal follow-up is envisioned after initial intervention.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
150
behavioral adaptation and symptom management
Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery
Hanover, Germany
RECRUITINGOccurrence of adverse events (composite endpoint)
Time frame: at month 60
Adherence behavior measurement variables from MEMS system
Time frame: first 3 month
Immunosuppression level
Time frame: Month 3, 12 and 60
All individual components of the composite endpoint occurence of adverse events
Time frame: at month 60
Immunosuppression level
Time frame: month 12
Immunosuppression level
Time frame: at month 60
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