The purpose of this study is to determine whether cultivated stem cell transplantation is effective for the treatment of patients wtih corneal stem cell deficiency.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
21
A limbal biopsy taken from the contralateral good eye in cases of unilateral disease or from a living related or cadaveric donor in cases of bilateral disease. The limbal stem cells from the biopsy are cultivated until a sheet of cells measuring approximately 12mm in diameter is obtained. This is then ready for transplantation onto the diseased eye.
University Hospital Antwerp
Antwerp, Edegem, Belgium
Visual Acuity
Time frame: Just before surgery and upto 1 years after surgery
Conjunctivalization
Time frame: Just before surgery and upto 1 years after surgery
Vascularization
Time frame: Just before surgery and upto 1 years after surgery
Epithelialization
Time frame: Just before surgery and upto 1 years after surgery
Prolonged subsequent corneal graft survival time
Time frame: 1 year post corneal transplant
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