Metabolic Effects of Switching to Aripiprazole in Patients With Bipolar Disorders

Inclusion Criteria: * patients with bipolar disorders (I, II, NOS) diagnosed with DSM-IV criteria * age between 18 and 65 * Decisional capacity is adequate to provide informed consent or has an authorized appropriate surrogate decision maker. in a syndromal remission state at least for 2 months : CGI - BP ≤ 3 * patients who have exhibited a clinically significant increase in body weight after starting the administration of their current antipsychotic (ie \>7% weight gain) Exclusion Criteria: * diagnosis of eating disorder, substance abuse, and psychotic disorder * history of neurological and medical illness * pregnant or breast feeding women