Assessment of Arformoterol for Chronic Obstructive Pulmonary Disease (COPD) Using Hyperpolarized 3He MRI

Inclusion Criteria: * Are male or female and are 50 years or older * Consent from the patient * Have been diagnosed with COPD * Must be able to hold their breath for up to 12 seconds * Must have a baseline FEV1 ≤ 80% of predicted but FEV1 \> 0.70 L * Must have a smoking history of 15 or more packs per year * Must have a breathlessness severity of ≥ 2 on the Medical Research Council dyspnea scale * Must be able to safely discontinue their respiratory medications for at least 12 hours. Exclusion Criteria: * Have any contraindications to an MR exam such as a pace-maker, metallic cardiac valves, magnetic material (i.e., surgical clips) implanted electronic infusion pumps or any other conditions that would preclude proximity to a strong magnetic field * Are undergoing the MR exam in an emergency situation * Are pregnant or become pregnant at any point within the study time. * People with psychiatric disorders will be excluded from the study. * Are claustrophobic and can not tolerate the imaging. * Uses supplemental oxygen * Have life-threatening or unstable respiratory status within 30 days before screening * Have a diagnosis of asthma and/or any chronic respiratory disease other than COPD * Have a lung resection greater than 1 full lobe * Have coronary artery disease or congestive heart failure * Are allergic to Arformoterol or similarly related drugs. * Are taking any of the drugs listed in the risks section and are unable to stop taking them.