PET Imaging Study on Occupancy of Dopamine D2 Receptors and Genotypes After Bupropion Administration

Seoul National University Hospital12 enrolled

Overview

Bupropion has different effects on D2 dopamine receptors according to genotype.

Open, one arm, single sequence, 2-period, study stratified into 2 DRD2 genotype groups For subjects who volunteer to cease smoking, genotypes are investigated. Twelve subjects are enrolled (6 - DRD2 Taq1A1 allele, 6 - DRD2 Taq1A2 homozygotes). Subjects receive baseline raclopride PET (High Specific Activity, Low Specific Activity). * Period 1 Subjects receive 150 mg of bupropion SR every day. After 1 week of medication, pharmacokinetic and PET studies are performed. * Period 2 Subjects receive 150 mg of bupropion SR twice a day. After 1 week of medication, pharmacokinetic and PET studies are performed.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Smoking

Interventions

BupropionDRUG

bupropion

Eligibility

Sex: MALEMin age: 20 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Active smoker (more than 10 cigarettes per day for the past 2 years) Exclusion Criteria: * Medical or psychiatric co-morbidity * Hypersensitive to bupropion

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Dopamine receptor occupancy

Time frame: 1 week

Secondary Outcomes

Pharmacokinetic parameters of bupropion and hydroxybupropion

Time frame: 1 week

Data from ClinicalTrials.gov

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