Hyperpolarized Noble Gas MR Imaging for Pulmonary Disorders

University of Massachusetts, Worcester14 enrolled

Overview

The purpose of this study is to test the efficacy of Hyperpolarized Helium-3 gas in MR imaging in COPD, asthmatics, CF and healthy volunteers.

Current pulmonary imaging techniques are clinically regulated to machines that produce radiation. MR which does not produce radiation was not possible due to the low concentration of fluids in the open spaces of the lungs. With hyperpolarized noble gases we can now use the safe techniques of MR imaging to view the airways of the lungs, thus limiting human exposure to radiation. This technique has already been proven to be possible in human subjects but there is insufficient data show its efficacy in a clinical setting. This study is designed to image a variety of pulmonary disorders to better find possible clinical uses for hyperpolarized gas MRI.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

COPD Cystic Fibrosis Asthma Healthy

Interventions

Hyperpolarized Helium-3DRUG

Patients will be required to breath in individual 1 liter bags of gas while in an MRI to produce lung images. These bags of gas are each made up of 333mL of Helium-3 gas and 667mL of Nitrogen. Three bags will be administered to acquire three different scans.

Eligibility

Sex: ALLMin age: 5 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Are male or female and are 5 years or older * Consent/assent from the patient * Have been diagnosed with a pulmonary disease such as COPD, Asthma, or cystic fibrosis. OR Healthy Individuals. * Must be able to hold their breath for up to 15 seconds Exclusion Criteria: * Have any contraindications to an MR exam such as a pace-maker, metallic cardiac valves, magnetic material (i.e., surgical clips) implanted electronic infusion pumps or any other conditions that would preclude proximity to a strong magnetic field; * Are undergoing the MR exam in an emergency situation * Are pregnant or become pregnant at any point within the study time. * People with psychiatric disorders will be excluded from the study. * Are claustrophobic and can not tolerate the imaging. * Uses supplemental oxygen

Locations (1)

UMASS Medical School Advanced MRI Center United States

Worcester, Massachusetts, United States

Outcomes

Primary Outcomes

Hyperpolarized Helium-3 MR Images

We have applied hyperpolarized 3He MR imaging to a range of subject with various disorders. We have developed our scanning techniques so as to acquire optimized images for each disorder.

Time frame: 15 second breath-hold

Data from ClinicalTrials.gov

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