Effects of H1-Antagonist on Cognition

Maastricht University Medical Center18 enrolled

Overview

The purpose of this study is to determine whether histamine is involved in memory and specific processes in human cognition.

The neurotransmitter histamine appears to be involved in human cognitive performance. However, the exact role is very unclear. The role it plays in memory performance is highly disputed, as animal studies show decreased performance when the H1-receptor is blocked in the central nervous system while such findings in humans is scarce. To clarify the role of histamine in human memory and different processes in cognition, the effects of an H1-antagonist (dexchlorpheniramine) on memory, alertness and sensory and motor processes are measured. The study will be conducted according to a within subject cross-over design using healthy volunteers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Cognition

Interventions

dexchlorpheniramine, lorazepamDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy as determined by a physician Exclusion Criteria: * present or history of any neurological of psychiatric disease * present or history of any substance abuse

Locations (1)

Faculty of Psychology and Neuroscience, Maastricht University

Maastricht, Limburg, Netherlands

Outcomes

Primary Outcomes

P300 latency and LRP onset latency

Time frame: 1.5 hours after treatment

Secondary Outcomes

Words recalled

Time frame: 1.5 hours after treatment

Data from ClinicalTrials.gov

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